SuicidDentistV1, Main, Exploration, bibRecord, 000209

Simvastatin prevents alveolar bone loss in an experimental rat model of periodontitis after ovariectomy.

Identifieur interne : 000209 ( Main/Exploration ); précédent : 000208; suivant : 000210

Simvastatin prevents alveolar bone loss in an experimental rat model of periodontitis after ovariectomy.

Auteurs : Xin-Chen Xu [République populaire de Chine] ; Hui Chen [République populaire de Chine] ; Xi Zhang [République populaire de Chine] ; Zan-Jing Zhai [République populaire de Chine] ; Xu-Qiang Liu [République populaire de Chine] ; An Qin [République populaire de Chine] ; Er-Yi Lu [République populaire de Chine]

Source :

Journal of translational medicine [ 1479-5876 ] ; 2014.

RBID : pubmed:25269614

Descripteurs français

KwdFr :
- Animaux (MeSH), Cément dentaire (anatomopathologie), Cément dentaire (effets des médicaments et des substances chimiques), Femelle (MeSH), Fémur (effets des médicaments et des substances chimiques), Fémur (physiopathologie), Marqueurs biologiques (sang), Microtomographie aux rayons X (MeSH), Modèles animaux de maladie humaine (MeSH), Numération cellulaire (MeSH), Ostéocalcine (sang), Ostéoclastes (anatomopathologie), Ostéoclastes (effets des médicaments et des substances chimiques), Ostéogenèse (effets des médicaments et des substances chimiques), Ovariectomie (effets indésirables), Parodontite (anatomopathologie), Parodontite (sang), Parodontite (traitement médicamenteux), Parodontite (étiologie), Phénomènes biomécaniques (effets des médicaments et des substances chimiques), Rat Sprague-Dawley (MeSH), Résorption alvéolaire (imagerie diagnostique), Résorption alvéolaire (prévention et contrôle), Résorption alvéolaire (traitement médicamenteux), Résorption alvéolaire (étiologie), Simvastatine (pharmacologie), Simvastatine (usage thérapeutique), Émail dentaire (anatomopathologie), Émail dentaire (effets des médicaments et des substances chimiques).
MESH :
- anatomopathologie : Cément dentaire, Ostéoclastes, Parodontite, Émail dentaire.
- effets des médicaments et des substances chimiques : Cément dentaire, Fémur, Ostéoclastes, Ostéogenèse, Phénomènes biomécaniques, Émail dentaire.
- effets indésirables : Ovariectomie.
- imagerie diagnostique : Résorption alvéolaire.
- pharmacologie : Simvastatine.
- physiopathologie : Fémur.
- prévention et contrôle : Résorption alvéolaire.
- sang : Marqueurs biologiques, Ostéocalcine, Parodontite.
- traitement médicamenteux : Parodontite, Résorption alvéolaire.
- usage thérapeutique : Simvastatine.
- étiologie : Parodontite, Résorption alvéolaire.
- Animaux, Femelle, Microtomographie aux rayons X, Modèles animaux de maladie humaine, Numération cellulaire, Rat Sprague-Dawley.

English descriptors

KwdEn :
- Alveolar Bone Loss (diagnostic imaging), Alveolar Bone Loss (drug therapy), Alveolar Bone Loss (etiology), Alveolar Bone Loss (prevention & control), Animals (MeSH), Biomarkers (blood), Biomechanical Phenomena (drug effects), Cell Count (MeSH), Dental Cementum (drug effects), Dental Cementum (pathology), Dental Enamel (drug effects), Dental Enamel (pathology), Disease Models, Animal (MeSH), Female (MeSH), Femur (drug effects), Femur (physiopathology), Osteocalcin (blood), Osteoclasts (drug effects), Osteoclasts (pathology), Osteogenesis (drug effects), Ovariectomy (adverse effects), Periodontitis (blood), Periodontitis (drug therapy), Periodontitis (etiology), Periodontitis (pathology), Rats, Sprague-Dawley (MeSH), Simvastatin (pharmacology), Simvastatin (therapeutic use), X-Ray Microtomography (MeSH).
MESH :
- chemical , blood : Biomarkers, Osteocalcin.
- adverse effects : Ovariectomy.
- blood : Periodontitis.
- diagnostic imaging : Alveolar Bone Loss.
- drug effects : Biomechanical Phenomena, Dental Cementum, Dental Enamel, Femur, Osteoclasts, Osteogenesis.
- drug therapy : Alveolar Bone Loss, Periodontitis.
- etiology : Alveolar Bone Loss, Periodontitis.
- pathology : Dental Cementum, Dental Enamel, Osteoclasts, Periodontitis.
- chemical , pharmacology : Simvastatin.
- physiopathology : Femur.
- prevention & control : Alveolar Bone Loss.
- chemical , therapeutic use : Simvastatin.
- Animals, Cell Count, Disease Models, Animal, Female, Rats, Sprague-Dawley, X-Ray Microtomography.

Abstract

BACKGROUND

Periodontitis is an inflammatory disease characterized by the loss of connective tissue and alveolar bone. There is an increasing evidence that periodontitis is associated with a number of chronic disease, including osteoporosis. Periodontitis and osteoporosis are both bone destructive diseases and of high prevalence in adult population. Osteoporosis could increase some inflammatory factors that also participate in the progression of periodontitis, so as to facilitate the alveolar bone resorption. Simvastatin, specific inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme reductase, is of pleiotropic effects including anti-catabolic and anabolic effect on bone metabolism. This study aimed to explore the local and systemic effect of simvastatin on maxillary in rats with both osteoporosis and periodontitis.

METHODS

Thirty-six 4-month-old female Sprague Dawley rats were randomly assigned to six groups: sham group, ligature group, ovariectomized (OVX) + ligature group, local simvastatin administration to OVX + ligature rats (local simvastatin group), oral simvastatin administration to OVX + ligature rats (oral simvastatin group), local and oral simvastatin administration to OVX + ligature rats (L&O simvastatin group). One month after OVX, ligatures were placed on the maxillary first (M1) and second molars (M2) for 4 weeks on all rats except those in the sham group, followed by simvastatin treatment for 2 months. The maxillae, serum, and femurs were collected for further examination including micro-computed (micro-CT) tomography, hematoxylin and eosin (H&E) staining, tartrate-resistant acid phosphatase (TRAP) staining, enzyme-linked immunosorbent assays (ELISA), and the three-point bending test.

RESULTS

Local simvastatin administration increased alveolar crest height and prevented local alveolar bone loss without alteration of systemic bone loss. Oral administration prevented local and systemic bone loss with no effect on alveolar crest height.

CONCLUSIONS

Our results indicate that simvastatin has the potential of promoting bone formation and reducing alveolar bone loss in maxillary following ovariectomy (OVX) and ligature placement in rats.

DOI: 10.1186/s12967-014-0284-0
PubMed: 25269614
PubMed Central: PMC4192445

Affiliations:

République populaire de Chine

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000192
to stream Main, to step Curation: 000192

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alveolar Bone Loss (diagnostic imaging)</term>
<term>Alveolar Bone Loss (drug therapy)</term>
<term>Alveolar Bone Loss (etiology)</term>
<term>Alveolar Bone Loss (prevention & control)</term>
<term>Animals (MeSH)</term>
<term>Biomarkers (blood)</term>
<term>Biomechanical Phenomena (drug effects)</term>
<term>Cell Count (MeSH)</term>
<term>Dental Cementum (drug effects)</term>
<term>Dental Cementum (pathology)</term>
<term>Dental Enamel (drug effects)</term>
<term>Dental Enamel (pathology)</term>
<term>Disease Models, Animal (MeSH)</term>
<term>Female (MeSH)</term>
<term>Femur (drug effects)</term>
<term>Femur (physiopathology)</term>
<term>Osteocalcin (blood)</term>
<term>Osteoclasts (drug effects)</term>
<term>Osteoclasts (pathology)</term>
<term>Osteogenesis (drug effects)</term>
<term>Ovariectomy (adverse effects)</term>
<term>Periodontitis (blood)</term>
<term>Periodontitis (drug therapy)</term>
<term>Periodontitis (etiology)</term>
<term>Periodontitis (pathology)</term>
<term>Rats, Sprague-Dawley (MeSH)</term>
<term>Simvastatin (pharmacology)</term>
<term>Simvastatin (therapeutic use)</term>
<term>X-Ray Microtomography (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Cément dentaire (anatomopathologie)</term>
<term>Cément dentaire (effets des médicaments et des substances chimiques)</term>
<term>Femelle (MeSH)</term>
<term>Fémur (effets des médicaments et des substances chimiques)</term>
<term>Fémur (physiopathologie)</term>
<term>Marqueurs biologiques (sang)</term>
<term>Microtomographie aux rayons X (MeSH)</term>
<term>Modèles animaux de maladie humaine (MeSH)</term>
<term>Numération cellulaire (MeSH)</term>
<term>Ostéocalcine (sang)</term>
<term>Ostéoclastes (anatomopathologie)</term>
<term>Ostéoclastes (effets des médicaments et des substances chimiques)</term>
<term>Ostéogenèse (effets des médicaments et des substances chimiques)</term>
<term>Ovariectomie (effets indésirables)</term>
<term>Parodontite (anatomopathologie)</term>
<term>Parodontite (sang)</term>
<term>Parodontite (traitement médicamenteux)</term>
<term>Parodontite (étiologie)</term>
<term>Phénomènes biomécaniques (effets des médicaments et des substances chimiques)</term>
<term>Rat Sprague-Dawley (MeSH)</term>
<term>Résorption alvéolaire (imagerie diagnostique)</term>
<term>Résorption alvéolaire (prévention et contrôle)</term>
<term>Résorption alvéolaire (traitement médicamenteux)</term>
<term>Résorption alvéolaire (étiologie)</term>
<term>Simvastatine (pharmacologie)</term>
<term>Simvastatine (usage thérapeutique)</term>
<term>Émail dentaire (anatomopathologie)</term>
<term>Émail dentaire (effets des médicaments et des substances chimiques)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term>
<term>Osteocalcin</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Ovariectomy</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cément dentaire</term>
<term>Ostéoclastes</term>
<term>Parodontite</term>
<term>Émail dentaire</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Periodontitis</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Alveolar Bone Loss</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Biomechanical Phenomena</term>
<term>Dental Cementum</term>
<term>Dental Enamel</term>
<term>Femur</term>
<term>Osteoclasts</term>
<term>Osteogenesis</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Alveolar Bone Loss</term>
<term>Periodontitis</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Cément dentaire</term>
<term>Fémur</term>
<term>Ostéoclastes</term>
<term>Ostéogenèse</term>
<term>Phénomènes biomécaniques</term>
<term>Émail dentaire</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Ovariectomie</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Alveolar Bone Loss</term>
<term>Periodontitis</term>
</keywords>
<keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Résorption alvéolaire</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dental Cementum</term>
<term>Dental Enamel</term>
<term>Osteoclasts</term>
<term>Periodontitis</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Simvastatine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Simvastatin</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Fémur</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Femur</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Alveolar Bone Loss</term>
</keywords>
<keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Résorption alvéolaire</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Marqueurs biologiques</term>
<term>Ostéocalcine</term>
<term>Parodontite</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Simvastatin</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Parodontite</term>
<term>Résorption alvéolaire</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Simvastatine</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Parodontite</term>
<term>Résorption alvéolaire</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Count</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Rats, Sprague-Dawley</term>
<term>X-Ray Microtomography</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Femelle</term>
<term>Microtomographie aux rayons X</term>
<term>Modèles animaux de maladie humaine</term>
<term>Numération cellulaire</term>
<term>Rat Sprague-Dawley</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Periodontitis is an inflammatory disease characterized by the loss of connective tissue and alveolar bone. There is an increasing evidence that periodontitis is associated with a number of chronic disease, including osteoporosis. Periodontitis and osteoporosis are both bone destructive diseases and of high prevalence in adult population. Osteoporosis could increase some inflammatory factors that also participate in the progression of periodontitis, so as to facilitate the alveolar bone resorption. Simvastatin, specific inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme reductase, is of pleiotropic effects including anti-catabolic and anabolic effect on bone metabolism. This study aimed to explore the local and systemic effect of simvastatin on maxillary in rats with both osteoporosis and periodontitis.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Thirty-six 4-month-old female Sprague Dawley rats were randomly assigned to six groups: sham group, ligature group, ovariectomized (OVX) + ligature group, local simvastatin administration to OVX + ligature rats (local simvastatin group), oral simvastatin administration to OVX + ligature rats (oral simvastatin group), local and oral simvastatin administration to OVX + ligature rats (L&O simvastatin group). One month after OVX, ligatures were placed on the maxillary first (M1) and second molars (M2) for 4 weeks on all rats except those in the sham group, followed by simvastatin treatment for 2 months. The maxillae, serum, and femurs were collected for further examination including micro-computed (micro-CT) tomography, hematoxylin and eosin (H&E) staining, tartrate-resistant acid phosphatase (TRAP) staining, enzyme-linked immunosorbent assays (ELISA), and the three-point bending test.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Local simvastatin administration increased alveolar crest height and prevented local alveolar bone loss without alteration of systemic bone loss. Oral administration prevented local and systemic bone loss with no effect on alveolar crest height.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Our results indicate that simvastatin has the potential of promoting bone formation and reducing alveolar bone loss in maxillary following ovariectomy (OVX) and ligature placement in rats.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25269614</PMID>
<DateCompleted><Year>2016</Year>
<Month>03</Month>
<Day>14</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1479-5876</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>12</Volume>
<PubDate><Year>2014</Year>
<Month>Oct</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>Journal of translational medicine</Title>
<ISOAbbreviation>J Transl Med</ISOAbbreviation>
</Journal>
<ArticleTitle>Simvastatin prevents alveolar bone loss in an experimental rat model of periodontitis after ovariectomy.</ArticleTitle>
<Pagination><MedlinePgn>284</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s12967-014-0284-0</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Periodontitis is an inflammatory disease characterized by the loss of connective tissue and alveolar bone. There is an increasing evidence that periodontitis is associated with a number of chronic disease, including osteoporosis. Periodontitis and osteoporosis are both bone destructive diseases and of high prevalence in adult population. Osteoporosis could increase some inflammatory factors that also participate in the progression of periodontitis, so as to facilitate the alveolar bone resorption. Simvastatin, specific inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme reductase, is of pleiotropic effects including anti-catabolic and anabolic effect on bone metabolism. This study aimed to explore the local and systemic effect of simvastatin on maxillary in rats with both osteoporosis and periodontitis.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Thirty-six 4-month-old female Sprague Dawley rats were randomly assigned to six groups: sham group, ligature group, ovariectomized (OVX) + ligature group, local simvastatin administration to OVX + ligature rats (local simvastatin group), oral simvastatin administration to OVX + ligature rats (oral simvastatin group), local and oral simvastatin administration to OVX + ligature rats (L&O simvastatin group). One month after OVX, ligatures were placed on the maxillary first (M1) and second molars (M2) for 4 weeks on all rats except those in the sham group, followed by simvastatin treatment for 2 months. The maxillae, serum, and femurs were collected for further examination including micro-computed (micro-CT) tomography, hematoxylin and eosin (H&E) staining, tartrate-resistant acid phosphatase (TRAP) staining, enzyme-linked immunosorbent assays (ELISA), and the three-point bending test.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Local simvastatin administration increased alveolar crest height and prevented local alveolar bone loss without alteration of systemic bone loss. Oral administration prevented local and systemic bone loss with no effect on alveolar crest height.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our results indicate that simvastatin has the potential of promoting bone formation and reducing alveolar bone loss in maxillary following ovariectomy (OVX) and ligature placement in rats.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Xin-chen</ForeName>
<Initials>XC</Initials>
<AffiliationInfo><Affiliation>Department of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai, 200011, China. xuxinchen88@163.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Hui</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai, 200011, China. amychen.dentist@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Xi</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai, 200011, China. summerflowergarden@126.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhai</LastName>
<ForeName>Zan-jing</ForeName>
<Initials>ZJ</Initials>
<AffiliationInfo><Affiliation>Department of Orthopaedic, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, 639 Zhizaoju Road, Shanghai, 200011, China. eryijiuyuan@163.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Xu-qiang</ForeName>
<Initials>XQ</Initials>
<AffiliationInfo><Affiliation>Department of Orthopaedic, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, 639 Zhizaoju Road, Shanghai, 200011, China. shliuxuqiang@163.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Qin</LastName>
<ForeName>An</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Orthopaedic, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, 639 Zhizaoju Road, Shanghai, 200011, China. dr.qinan@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lu</LastName>
<ForeName>Er-yi</ForeName>
<Initials>EY</Initials>
<AffiliationInfo><Affiliation>Department of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai, 200011, China. lueryi222@126.com.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>10</Month>
<Day>01</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Transl Med</MedlineTA>
<NlmUniqueID>101190741</NlmUniqueID>
<ISSNLinking>1479-5876</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>104982-03-8</RegistryNumber>
<NameOfSubstance UI="D015675">Osteocalcin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>AGG2FN16EV</RegistryNumber>
<NameOfSubstance UI="D019821">Simvastatin</NameOfSubstance>
</Chemical>
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<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D016301" MajorTopicYN="N">Alveolar Bone Loss</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001696" MajorTopicYN="N">Biomechanical Phenomena</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002452" MajorTopicYN="N">Cell Count</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003739" MajorTopicYN="N">Dental Cementum</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003743" MajorTopicYN="N">Dental Enamel</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005269" MajorTopicYN="N">Femur</DescriptorName>
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<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015675" MajorTopicYN="N">Osteocalcin</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010010" MajorTopicYN="N">Osteoclasts</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010012" MajorTopicYN="N">Osteogenesis</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010052" MajorTopicYN="N">Ovariectomy</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010518" MajorTopicYN="N">Periodontitis</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019821" MajorTopicYN="N">Simvastatin</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055114" MajorTopicYN="N">X-Ray Microtomography</DescriptorName>
</MeshHeading>
</MeshHeadingList>
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<Day>25</Day>
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<affiliations><list><country><li>République populaire de Chine</li>
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<name sortKey="Lu, Er Yi" sort="Lu, Er Yi" uniqKey="Lu E" first="Er-Yi" last="Lu">Er-Yi Lu</name>
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	Serveur d'exploration sur le suicide chez les dentistes
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Simvastatin prevents alveolar bone loss in an experimental rat model of periodontitis after ovariectomy.

Simvastatin prevents alveolar bone loss in an experimental rat model of periodontitis after ovariectomy.

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